Research Progress on Original Detection, Allergy-Reducing Processing and Desensitization Treatment in the Production Process of Hypoallergenic Peanut Products
Abstract
Peanuts are one of the common food allergens worldwide, posing a serious health threat to those who are allergic to peanuts. With the development of food technology, developing hypoallergenic peanut products has become an important way to meet the needs of allergic groups. This paper explores the original detection, desensitization treatment techniques, and research progress of desensitization treatment in the production process of allergic peanut products. This paper first introduces the allergy principle of hypoallergenic peanut products, then examines the existing detection methods, deepens the desensitization treatment technology, and introduces the research status of desensitization therapy. Then, the research method proposed in this paper is elaborated in detail, including the specific steps of initial detection, the implementation details of desensitization therapy technology, and the experimental design of desensitization therapy. Finally, the experimental results showed that the original detection accuracy of low allergenic peanut products was 0.7-0.85. This indicates that methods to reduce sensitivity can work more accurately in various evaluation aspects and achieve expected results more reliably in allergy response management scenarios.
References
[1] Wang Y, He S, Zhou F, et al. Detection of lectin protein allergen of kidney beans (Phaseolus vulgaris L.) and desensitization food processing technology[J]. Journal of Agricultural and Food Chemistry, 2021, 69(49): 14723-14741.
[2] Geng Q, Zhang Y, Song M, et al. Allergenicity of peanut allergens and its dependence on the structure[J]. Comprehensive Reviews in Food Science and Food Safety, 2023, 22(2): 1058-1081.
[3] Zhou E, Li Q, Zhu D, et al. Characterization of physicochemical and immunogenic properties of allergenic proteins altered by food processing: a review[J]. Food Science and Human Wellness, 2024, 13(3): 1135-1151.
[4] Mulalapele L T, Xi J. Detection and inactivation of allergens in soybeans: A brief review of recent research advances[J]. Grain & Oil Science and Technology, 2021, 4(4): 191-200.
[5] Wang J, He Z, Raghavan V. Soybean allergy: characteristics, mechanisms, detection and its reduction through novel food processing techniques[J]. Critical Reviews in Food Science and Nutrition, 2023, 63(23): 6182-6195.
[6] Mousavi Khaneghah A, Nematollahi A, AbdiMoghadam Z, et al. Research progress in the application of emerging technology for reducing food allergens as a global health concern: A systematic review[J]. Critical Reviews in Food Science and Nutrition, 2024, 64(27): 9789-9804.
[7] Suriyamoorthy P, Madhuri A, Tangirala S, et al. Comprehensive review on banana fruit allergy: pathogenesis, diagnosis, management, and potential modification of allergens through food processing[J]. Plant Foods for Human Nutrition, 2022, 77(2): 159-171.
[8] Larsen J M, Bang-Berthelsen C H, Qvortrup K, et al. Production of allergen-specific immunotherapeutic agents for the treatment of food allergy[J]. Critical reviews in biotechnology, 2020, 40(6): 881-894.
[9] Peters R L, Krawiec M, Koplin J J, et al. Update on food allergy[J]. Pediatric Allergy and Immunology, 2021, 32(4): 647-657.
[10] La Vieille S, Hourihane J O B, Baumert J L. Precautionary allergen labeling: what advice is available for health care professionals, allergists, and allergic consumers?[J]. The Journal of Allergy and Clinical Immunology: In Practice, 2023, 11(4): 977-985.
[11] Ayass M A, Tripathi T, Griko N, et al. AYA22A Aptamers Mitigate Peanut Allergenicity: Insights from Degranulation Assays and Modulating Immune Responses[J]. Allergies, 2024, 4(3): 94-123.
[12] Nagendran S, Patel N, Turner P J. Oral immunotherapy for food allergy in children: is it worth it?[J]. Expert Review of Clinical Immunology, 2022, 18(4): 363-376.
[13] Šošić L, Paolucci M, Flory S, et al. Allergen immunotherapy: progress and future outlook[J]. Expert Review of Clinical Immunology, 2023, 19(7): 745-769.
[14] Fernandez‐Rivas M, Vereda A, Vickery B P, et al. Open‐label follow‐on study evaluating the efficacy, safety, and quality of life with extended daily oral immunotherapy in children with peanut allergy[J]. Allergy, 2022, 77(3): 991-1003.
[15] Casale T B, Irani A M. Peanut (Arachis hypogaea) allergen powder-dnfp for the mitigation of allergic reactions to peanuts in children and adolescents[J]. Expert Review of Clinical Immunology, 2023, 19(3): 253-265.
[16] OHTSUKA Y. Mechanisms of Food Allergy/Intolerance and Oral Desensitization Therapy[J]. Juntendo Medical Journal, 2020, 66(6): 497-506.
[17] Wu H, Chen B, Wu Y, et al. New perspectives on food matrix modulation of food allergies: Immunomodulation and component interactions[J]. Journal of Agricultural and Food Chemistry, 2023, 71(36): 13181-13196.
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